Welcome to this interactive, web-based MSG Educational Committee activity entitled Early Diagnosis and Management of Invasive Fungal Infections: Are We There Yet? 

Dear colleague,

 We are pleased that you have joined us for this enduring activity based on highlights of the live ICAAC 2012 Satellite Symposium, September 8, 2012, in San Francisco.

While early diagnosis and initiation of appropriate antifungal therapy are crucial to assure optimal outcomes for patients with invasive mycoses, there are many barriers to early, effective management. Better screening methods and newer diagnostic techniques, when effectively employed, should enable more rapid and accurate diagnoses of these challenging infections. Furthermore, appropriate use of current and emerging antifungals with enhanced antifungal spectra should also afford better outcomes despite changing epidemiologic trends and the emergence of resistant pathogens. This activity addresses the question of whether we have entered an era in which appropriate diagnostics and therapeutics can be employed early in the management of invasive mycoses to improve antifungal outcomes.

I am pleased to be joined by our excellent faculty, Nelesh Govender, Thomas F. Patterson, George R. Thompson, Jose A. Vazquez, and Paul Verweij, as we address this issue across the spectrum of invasive mycoses. You will have the option of reviewing overviews on therapeutics and diagnostics from Tom Patterson and me as well as the case-based discussions in the areas of aspergillosis, candidiasis, crypotococcosis, and endemic infections. Throughout the activity, you will be given the opportunity to answer challenge questions at major decision points in each case. After each decision point, the faculty will provide the best answer and review the rationale for that answer. After completing each case, you will be given the opportunity to revisit these questions as part of the posttest evaluation. We hope that you find this interactive activity for this challenging condition engaging and educationally worthwhile.


Peter Pappas


Peter G. Pappas, MD, FACP

William E. Dismukes Professor of Medicine
Principal Investigator, Mycoses Study Group
Division of Infectious Diseases
University of Alabama at Birmingham
Birmingham, Alabama

Sponsored by The University of Nebraska Medical Center, TerraNova Medica, and The MSG Educational Committee
Supported by Educational Grants from: Astellas, IMMY, Luminex, MiraVista Diagnostics, T2 Biosysems, and Viraco IBT

Aspergillus fumigatus image provided courtesy of Dr. David Ellis and the University of Adelaide.
Cryptococcus neoformans image provided courtesy of Gross L (2006) Iron Regulation and an Opportunistic AIDS-Related Fungal Infection. PLoS Biol 4(12): e427. doi:10.1371/journal.pbio.0040427